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Myth: Massaging the area helps the B12 spread and work faster Reality: Massaging may spread the fluid and increase bruising or soreness without improving how the vitamin works

Blood samples taken at five and 13 years after the start of the study showed that average vitamin B12 levels were lower among participants on metformin at the five-year mark

The researchers noted a clear dose-response relationship, where higher doses yielded better clinical outcomes, particularly in patients who carried variations in the MTHFR gene

Meal timing: Smaller, more frequent meals help some people handle GI effects during early titration

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