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Description

The combined samples were desalted with a Sep-Pak C18 cartridge and offline-fractionated by HPLC

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The --ketoalkene formed through primary filter deamination undergoes reduction to form AHBG (94), binds to GSH to create GSH-3OHKG (117), or free cysteine (118), and can bind to proteins through lysine, cysteine and histidine (119)

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Population pharmacokinetics and pharmacodynamics of gabapentin after administration of gabapentin enacarbil

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