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[29, 30, 31] Senomorphics, on the other hand, primarily inhibit various inflammatory factors in the SASP, such as interleukin-6 (IL-6), IL-10 and tumor necrosis factor (TNF) via disrupting upstream signaling pathways, among which are nuclear factor kappa-B (NF-B), protein 38 mitogen-activated protein kinase (p38MAPK), silent information regulator transcript 1 (SIRT1), Janus kinase/signal transducer and activator of transcription (JAK/STAT) and nuclear factor erythroid 2-related factor 2 (NRF2)

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Additionally, there is a need to monitor dosages to avoid potential hepatotoxicity, particularly when combined with certain herbs that could interact with estrogen levels in the body