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(1995) J Immunol

ACLY, a key cytosolic enzyme that converts mitochondrial citrate to acetyl-CoA, exerts dual effects when inhibited, it not only activates the cGAS-STING innate immune pathway but also concomitantly upregulates PD-L1 expression in cancer cells

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After achieving the best efficient PPK-mutant enzyme, the addition of Ch PPK D82N-K103E can significantly improve the efficiency and sustainability of ATP regeneration, which will enhance the catalytic efficiency and save the cost in energy-demanding catalytic reactions

Activated microglia are an important type of innate immune cell in the brain that secrete inflammatory cytokines into the extracellular environment, where they exert neurotoxicity on surrounding neurons by releasing nitric oxide [35,36], and are involved in the pathogenesis of many brain disorders, including AD [37]