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At the same time, the development of innovative research methods, such as genome-wide association studies and multi-omics analyses, can more comprehensively reveal the biological basis of this complex relationship

Per-protocol sensitivity analyses indicated no change from overall population results

Both have shown efficacy in different models, and the choice depends on the specific research question

BMC Oral Health 23 (1), 612

In limited cutaneous SSc (lcSSc) there is no skin involvement proximal to the elbows and the knees (with the exception of the face and neck areas that can be involved), while diffuse cutaneous SSc (dcSSc) affects the skin in proximal areas such as the trunk