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Moreover, perturbation of the TCA cycle can disrupt bacterial energy homeostasis, leading to alterations in antibiotic targets or enhanced utilization of alternative metabolic pathways that significantly bolster bacterial viability (Yao et al., 2024)

Neisseria meningitidis lactate permease is required for nasopharyngeal colonization

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Hence, it was always anticipated that this would represent a precursor to a larger multicenter trial