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Wiwatchaitawee K, Ebeid K, Quarterman JC, Naguib Y, Ali MDY, Oliva C, Griguer C, Salem AK

Importantly, it has been demonstrated that SAMe levels must be tightly controlled, and dysregulation of its homeostasis through lack of its catabolism by glycine N-methyltrasferase (GNMT) leads to liver disease and hepatocellular carcinoma (HCC), process that may be compensated by other methyltransferase activities such as NAM-methyltransferase (NNMT) [34,35,36,37]

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Structure and sequence comparison of the EcGspS crystal structure (pdb: 2ioa

About the Author Leslie Goldman, MPH, Health Writer About the Reviewer Robert H