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A reliance on animal experiments may be misleading, given the substantial changes, not only in UA metabolism but also in its transport, associated with primate evolution 62

In pyroptosis, ROS act as a key upstream signal for activating the inflammasome, initiating the cleavage of gasdermin D (GSDMD) by caspase-1, leading to cell lysis and a massive inflammatory response [76, 77]

By producing O 2 radicals through the NADPH oxidases, the activated LOXs enhance the phagocytic responses to induce inflammation

Kimchi: A spicy fermented cabbage dish that is a staple in Korean cuisine

Bazan NG, de Abreu MT, Bazan HE, Belfort RJ