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The metabolomic difference between different generations PDX with chemotherapy treated was obvious Since important tumor-related metabolisms, such as TCA, can undergo reprogramming during the establishment and passage of PDX models, it is critical to investigate whether there are differences in the chemosensitivity and post-chemotherapy tumor metabolism among PDX models with different passages

HMGB1 upregulates TFR1 expression via Ras-JNK/p38 pathways, promoting ferroptosis (Ye et al., 2019)

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GHK-Cu is also thought to be a powerful antioxidant, which may support wound healing, reduce inflammation, and enhance skin regeneration

in chronic conditions of H 2 S deficiency, excessive SQOR activity may undermine the hearts intrinsic protective mechanisms