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Studies in animal models of ischemic stroke showed that lactate, either endogenously produced during hypoxia or applied exogenously at reoxygenation, supports energy metabolism and functional recovery in neurons 23,24,25,26 , and that direct intracerebroventricular or intravenous injection of lactate led to a decrease in infarct volume and an improvement in neurological outcome 26,27

Glutathione but not dTTP level determines JMF4073 susceptibility Next, we investigated whether the decrease in dTTP pool by SHMT2 knockdown could induce DNA replication stress and increase susceptibility to JMF4073 in T315I-Bcr-Abl-32D cells