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Identification of an efficacy switch region in the ghrelin receptor responsible for interchange between agonism and inverse agonism

Teichman SL et al., "Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults," Journal of Clinical Endocrinology & Metabolism, 2006

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However the group comprising the very old had the highest level of GH release followed by the group comprising the aged subjects with the "less than 40 yr group" experiencing a substantial rise but not as high as the other two groups