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doi:10.1016/j.procbio.2006.02.011 Rollini M, Musatti A, Manzoni M (2010) Production of glutathione in extracellular form by Saccharomyces cerevisiae

If those compounds reach a cluster of subclinical precancerous cells, the result could be the pharmacological equivalent of pouring accelerant on a fire that was quietly burning at undetectable levels

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And if twice-daily dosing failed to produce the effect that once-daily morning dosing did, the intuition that timing failures can be solved by adding another dose finds no support in the only data available