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Whether dysregulation of mTORC1 over aging is the trigger for the malfunction of key cellular processes, such as translation, autophagy, and lysosomal biogenesis, or vice versa is an important question that remains to be elucidated

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These findings show that AS3MT automethylation is governed by at least four cysteines C33, C62, C157, and C207, which are the same residues needed to catalyze arsenic methylation

Another study demonstrated that the combination of CAR-T cells and modified OVs expressing TNF- and IL-2 has a robust anti-tumor effect in the pancreatic ductal adenocarcinoma (PDA) murine model [48]

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