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doi: 10.1177/002221948201500605 155 SocietyCP

[121], in the vincristine-induced CIPN model, curcumin at doses of 30 and 60 mg/kg significantly increased the nociceptive threshold and levels of endogenous antioxidant enzymes, decreased vincristine-induced calcium accumulation, nitric oxide (NO), and lipid peroxidation (LPO) levels in the sciatic nerve of mice, and exerted analgesic, calcium inhibitory, neuroprotective, and antioxidant effects in a dose-dependent manner, which in turn ameliorated vincristine-induced neuropathy in mice