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It regulates mitochondrial activity through modulation of transcription factors and is a crucial cofactor in the -oxidation of fatty acids, which facilitates the cellular energy production process (Sahebnasagh et al., 2022), balancing hypertonicity-induced imbalances between oxygenase and antioxidant enzymes, reducing ROS production, inhibiting lipid peroxidation, preventing oxidative DNA damage, and suppressing the production of heme oxygenase-1 and cyclooxygenase-2

Therefore, the identified factors represent universal biomarkers of biological age acceleration, shared across diseases, tissues, species, and levels of molecular organization

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