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Cosmetic applications , They are used as anti-wrinkle treatments to relax facial muscles, thereby reducing the appearance of fine lines and wrinkles, specifically in areas such as the forehead, around the eyes (crow's feet), between the eyebrows (glabellar lines), and around the mouth (Smoker lines)

This category groups the small molecules and peptide fragments most investigated across those pathways so researchers can compare mechanism, format and documentation in one place

However, when this signal is too strong or prolonged, it damages liver cells, leading to disease progression

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10.1155/2021/9924314 85 LiuM.ChuJ.GuY.ShiH.ZhangR.WangL.et al (2017)