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At therapeutic IV doses (often 2550 g in oncology and critical-care research), studies report improvements in inflammation markers, oxidative stress, and quality of life in advanced cancer and sepsis, although evidence is strongest for adjunctive rather than standalone use

Pickart L, Vasquez-Soltero JM, Margolina A (2017) The effect of the human peptide GHK on gene expression relevant to nervous system function and cognitive decline

The halfway mark

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While retinol works primarily through cellular turnover acceleration, GHK-Cu addresses aging through multiple mechanisms including direct collagen stimulation, antioxidant protection, and barrier repair