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Acetaminophen and aspirin toxicity are both high yield, but the injury pattern is very different. Acetaminophen overdose overwhelms glutathione, allowing NAPQI to build up and cause hepatic necrosis. The antidote is N acetylcysteine, which Acetaminophen Toxicity Explained Stages, Diagnosis & N Acetylcysteine Treatment CanadaQBank Acetaminophen MSK Medbullets Step 1 Acetaminophen Toxicity and Liver Zone Physiology [#DaVinciCases GI 5 Physiology Case 3] What substance depletion causes hepatic necrosis from acetaminophen overdose ?
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