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Sustained endothelial progenitor cell dysfunction after chronic hypoxia-induced pulmonary hypertension

doi: 10.1038/s41561-018-0080-1 248 HwangG.-J.XieH.WahB

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Although HO-1 is commonly associated with cytoprotection and inhibition of cell death processes, excessive activation of HO-1 releases large amounts of Fe 2+ , leading to the accumulation of unstable iron pools and corresponding deleterious cyclic effects that exacerbate oxidative stress, presenting a dual effect that characterizes HO-1 as a double-edged sword

For instance, USP7 contributes to chemoresistance in cervical cancer by maintaining the stability of the Chk1 protein and reducing DNA damage responses