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Like many medications in this class, the most common side effects are nausea, diarrhea, or stomach upset , especially when starting treatment

In addition, many AMPs exhibit strong cytotoxicity on MDR tumor cell lines

Additionally, recent research has delved into the interplay between confinement and other physical cues (e.g., stiffness [90], viscoelasticity [142], and viscosity [161]) in relation to cancer cells, revealing their combined contributions to different cell processes

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This integrated analysis of the chromatin landscape and BCL-2 transcription in well-defined subtypes of CRPC with contrasting AR signaling activity 78 suggests that the increased BCL-2 expression in AR -/lo CRPC may result from not only a loss of AR-mediated BCL-2 repression but also active BCL-2 transcription mediated by other transcription factors such as NF-B, STAT3 and E2F1 33,36,42 bound to these newly available chromatin loci