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Since successful control of the asthma symptoms is still a challenge, some of the results described may provide helpful guidance in the development of new therapeutic approaches for the treatment of asthma

Similarly, the green fluorescent signals from AsGGT1 N300 -GFP, AsGGT1 Full -GFP, AsGGT3 N300 -GFP, and AsGGT3 Full -GFP were observed in the cytosol, although the fluorescent signal intensities were much weaker (data not shown)

2000), several studies have demonstrated good concordance of the assay with the in vivo transgenic rodent (TGR) somatic mutation assay and also high sensitivity of 92.1% (35 out of 38 chemicals correctly identified) for detecting human IARC group 1 and Group 2A carcinogens, comparable to the TGR assay with 90.3% (Kirkland et al

Further mechanistic investigations focused on the Stat3 signaling pathway, which is commonly activated in inflammatory and tumorrelated processes