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Interestingly, while (R)-crizotinib, the clinically used form, is inactive against MTH1, the (S)-enantiomer of crizotinib selectively inhibits MTH1 catalytic activity

10.1016/j.psj.2021.101513 23 HabottaO

Kang B-J, Kim H, Lee SK, et al

References: Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily

Surprisingly, however, this increase in ROS did not decrease vascular propensity of the cells when they differentiated into ECs but in fact produced ECs with greater angiogenic capacity