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GT 3 genotype was particularly prevalent in Nordic (57%), GT1 - in Middle East (49%)

To investigate the metabolite profile of Down syndrome using the model, we began by increasing by 50% the V max of CBS, since the gene for CBS is on chromosome 21 and is expressed at 150% of normal

The gut microbiota plays a crucial role in maintaining intestinal homeostasis, and disruptions in its composition and its metabolism can result in pathological damage to the intestines [5, 6]

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In the 24-week ASSERT study, treatment with odevixibat resulted in significant improvements in pruritus and reductions in bile acids versus placebo in patients with ALGS