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Acknowledgements The authors acknowledge financial support from the National Natural Science Foundation of China (grant no

However, the clinical study did not acomplish the main goal of a Phase IIb study by not showing differences over the placebo treatment under FDA current guidelines 4

Pekna has been supported by grants from Swedish Research Council (2024-02814), the Swedish state under the agreement between the Swedish government and the county councils, the ALF agreement (1005387), The Swedish Brain Foundation (FO2023-0157) and The Swedish Stroke Foundation

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NAD+ is a vital coenzyme involved in energy metabolism and DNA repair