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Animal studies confirmed that the recombinant Amuc_1100 protein improves gut barrier functionality and restrains the development of high-fat diet-induced obesity in mice (82)

Achieving site-specific transcranial drug delivery to closed-skull TBI patients may be more difficult than the authors imply: the subarachnoid space filled with circulating cerebrospinal fluid (CSF) is about 3-4 mm deep in humans (3), more than an order of magnitude deeper than in mice, permitting CSF to quickly remove drug molecules from a targeted cortical site

Clinical data of the patients were collected

Adaptation and dosimetric commissioning of a synchrotron-based proton beamline for FLASH experiments

JG: Conceptualization, Funding acquisition, Writing review & editing