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Binding kinetics and thermodynamics, autophagy induction, apoptosis, and self-renewal were evaluated via isothermal titration calorimetry, Western blotting, annexin V assays, and tumorsphere formation assays, whereas aptamer-cell interaction and intracellular drug accumulation were quantified using flow cytometry

In the mouse model, integrin 3 expression peaks during WOI, and if this increase is blocked, implantation is significantly inhibited with decreased embryo implantation number [64]

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The team has already patented the technology, and these mouse experiments represent proof that the concept works