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Importantly, this interaction seems to be critical for Mtb pathogenicity and dissemination in vivo: animal experiments with Mtb infection showed that Mtb harboring a PtpA mutant incapable of interacting with PRMT6, as well as Mtb ptpA , was less able to cause pathogenicity and dissemination in the mouse lung than wild-type Mtb

doi:10.1152/ajpregu.00556.2010

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