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Linares-FernndezSMorenoJLambertEMercier-GouyPVachezLVerrierBet alCombining an optimized mRNA template with a double purification process allows strong expression of in vitro transcribed mRNA

This is unusual for peptides, which are typically degraded in the gastrointestinal tract

Mechanistic studies have established that Dihexas procognitive and synaptogenic effects are mediated by the hepatocyte growth factor (HGF) / c-Met receptor system rather than by the classical AT 4 receptor, despite Dihexas structural origin as an angiotensin IV derivative

It requires understanding the regulatory landscape that made this formulation necessary, the molecular mechanisms that make it effective, and the practical protocols that separate meaningful results from wasted effort

doi: 10.3390/cancers15072076 82 AwasthiKHuangWCWeiCYHsuHYOhtaN