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If conjugation of HMCDs with anti-neoplastic agents increases the intracellular drug concentration, it is likely the conjugate will bind to different, or additional drug targets, increasing the potency relative to the unconjugated drug

6 cells/ml (OD 600 0.37)

Inhibition of DRP1 expressions or activity has been shown to significantly suppress tumor cell proliferation, invasion, and migration, while enhancing apoptosis and increasing synergistic responses to chemotherapy and radiotherapy [47, 48]

Additional pumping stations for sludge movement, final sedimentation tanks and larger aeration tanks further increase overall construction costs

Mol Cell Res 1773:12631284