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US Department of Health and Human Services Food, Food and Drug Administration & Center for Drug Evaluation and Research (CDER)

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Alzheimers disease (AD), the most common form of dementia worldwide 270,271 , is characterized at the molecular level by the accumulation of A plaques, tau neurofibrillary tangles (NFTs), declined NAD + levels, mitochondrial stress, and impaired mitophagy, occurring first in the medial temporal lobe and eventually spreading to temporal and parietal cortices, and cortex 112,242,243,270,271,272

The plan for steroid management should be individualised based on the patients current regimen and underlying health conditions