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70 Various strategies for lowering lipids, such as physical activity, weight loss and bariatric surgery, have been reported to have positive effects, but the use of lipid-lowering medicine does not seem to be effective at slowing the development of DN

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The complexity of human perioperative pathophysiology means combination therapies might be needed (for instance, an antioxidant plus an IL-1 blocker might work better than either alone, addressing multiple feedback loops)

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