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Banu, M

M.Lpez-MirandaJ

Although dryness (sicca) of the eyes and mouth are the classically described features, dryness of other mucosal surfaces and systemic manifestations, including fatigue and arthralgia, are common ( Digestive involvement is frequent in pSS, including autoimmune disorders, such as chronic atrophic gastritis, esophageal motility dysfunction, lymphocytic colitis, primary biliary cholangitis and autoimmune hepatitis ( pSS-related atrophic gastritis and associated PA may require parenteral or sublingual vitamin B12 supplementation (2)

Maintenance Treatment While there is no body of evidence available to answer the question of how long a patient treated with ziprasidone should remain on it, a maintenance study in patients who had been symptomatically stable and then randomized to continue ziprasidone or switch to placebo demonstrated a delay in time to relapse for patients receiving ziprasidone capsules [see Clinical Studies (14.1)]

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