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Anti-tumor angiogenesis increases the normalization of blood vessels, inhibits tumor hypoxia and the immunosuppressive TME, increases the effective drug concentrations in tumors, and enhances drug efficacy

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RIG-I (DDX58) interacts with MDA-5 and utilizes the mitochondrial adapter protein Cardif (IPS-1) to upregulate the expression of BH3-only proteins Puma and Noxa, thereby promoting intrinsic apoptosis in melanoma cells [162]

doi: 10.3389/fcimb.2016.00193 175 KosciuczukEMLisowskiPJarczakJMajewskaARzewuskaMZwierzchowskiLet al