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To view a copy of this licence, visit About this article Cite this article Huang, Y., Lu, Z., Liu, H

This indicates that targeting IL-8-positive neutrophils could be a potential therapy for AH.54 A newly identified subset of neutrophils, known as low-density neutrophils (LDNs), has been linked to alcohol exposure and shows distinctive characteristics that differentiate them from traditional neutrophil populations.49 LDNs exhibit functional exhaustion, meaning they have diminished capacity to perform typical neutrophil functions such as pathogen elimination and inflammation resolution.49 Additionally, they display resistance to macrophage efferocytosis, the process by which dying or dead cells are engulfed and cleared by macrophages.49 This impaired clearance exacerbates tissue damage and inflammation in the liver, further contributing to the progression of ALD.49 One of the hallmark defence mechanisms of neutrophils is the formation of NETs.46 NETs consist of DNA and cationic proteins, which serve to capture and neutralise pathogens.49 55 56 However, in the context of ALD, alcohol exposure disrupts the formation of NETs, leading to decreased pathogen clearance and exacerbation of liver inflammation.49 55 56 This impairment in NET formation reduces the ability of neutrophils to contain infections, contributing to the pathogenesis of liver injury in ALD

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