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10.1007/s12291-023-01147-y 190

For long-term use spanning more than one year, 12 weeks on followed by 8 weeks off is the advised structure to minimize cumulative receptor desensitization

YasudaHHoshinoYAndoJMiyachiMOsawaMHattoriNet al

Shirali, A

Paternal chromatin undergoes rapid remodeling post-fertilization, involving TET3-mediated oxidation of 5mC to 5hmC, which is dependent on mitochondrial-derived -KG [68]