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FIN56 induces the posttranslational degradation of GPX4 and the depletion of CoQ 10 , thereby inducing ferroptosis

For example, UA-induced cytokine expression is NF- B-mediated

These insights suggest that strategically maintaining acetate concentrations may serve as an innovative adjunct to current cancer therapies, offering a promising approach to improve patient outcomes

Novel formulations such as lipid nanoparticles, esterified derivatives, or intranasal carriers should be systematically compared for pharmacokinetics, bloodbrain barrier penetration, and clinical efficacy

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