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In improving the behavioral performance of mice, Lactobacillus rhamnosus JB-1 was included and found to affect the expression of GABA receptors in the brain in a region-dependent manner

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It is involved in the viral attachment and in the host cell entry: the S1 subunit is able to bind the angiotensin-converting enzyme 2 (ACE2) receptor while, in a second step, the S2 subunit allows the virus to enter the cell by membrane fusion (122)

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Therefore, long-term in vivo experimental results indicate that Cu-containing nanoparticles exhibit low toxicity, and when combined with PD-1/PD-L1 therapy, mice show no intrapulmonary tumor metastasis, with 60% survival rate at 50 days