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Initially, TMAO promotes foam cell formation through scavenger receptors in macrophages and downregulates main BA synthesizing enzymes cyp7a1 and cyp27a1, reducing intracellular BA levels and affecting hepatic CHO, BA production, and bile secretion, leading to hypercholesterolemia

Topical Applications Topical formulations containing glutathione are also available, but their effectiveness may be less pronounced compared to oral or IV methods

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[DOI] [PubMed] [Google Scholar] 63.Mittal D, Gubin MM, Schreiber RD, Smyth MJ

Comparison of solution structural flexibility and zinc binding domains for insulin, proinsulin, and miniproinsulin