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Hypoxia induces XBP1 mRNA expression and splicing in a HIF-1 independent manner, resulting in increased levels of activated XBP1 protein, and XBP1 loss severely inhibits tumour growth due to a reduced capacity for tumour cells to survive in hypoxic microenvironments in vitro and in vivo 79,80

In the study of TCM, molecular docking successfully predicted that geniposidic acid (GPA) forms a "T-hammer" binding conformation with the farnesoid X receptor (FXR), similar to that of the known agonist

Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model Ann Clin Lab Sci, 2015, cartilage-repair and osteoarthritis model PMID 25208511 Cox HD et al

The process of pigmentation is mediated by melanin, a complex polymer derived from the amino acid tyrosine, and pigment cells are called melanocytes

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