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doi: 10.1007/s12011-014-9992-9 36

Meanwhile, the intrinsic GPx-like activity of ACPP constantly consumes GSH with the assistance of H 2 O 2 and protection of generated ROS to break the antioxidant defense effect of the tumor and further inhibit GPX4 activity, ultimately promoting lipid peroxidation (LPO) accumulation and enhancing the ferroptosis effect