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This effect of AMPK signaling is in agreement with our previous studies showing that, despite having 15% and 40% of WT total and mitochondrial GSH levels (respectively), livers from nave GCLM KO mice maintain structural and functional integrity of the mitochondria and show induction of ER stress-related genes 17,38

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This protein is responsible for reabsorbing glucose back into the bloodstream, but SGLT2 inhibitors prevent this from happening, resulting in increased glucose excretion in the urine, which improves glycemic control in people with T2DM