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these or other epigenetic mechanisms may also be dysregulated in cNF

A deficiency of TNSALP in HPP leads to decreased overall ALP activity and subnormal ALP levels

2-OHE2) results in a decreased cancer risk, whereas increased excretion of other metabolites (e.g., 16-hydroxylation metabolites and catechol estrogen DNA adducts) is associated with increased cancer risk 10,28,29

Therefore, it is essential to design intelligent nano delivery platforms to enhance the bioavailability of Cur and, at the same time, leverage combined therapeutic approaches to better address the complex tumor microenvironment in vivo