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Nausea, vomiting, diarrhea, constipation, and appetite suppression are common with semaglutide

In preclinical studies, obese primates treated for eight weeks with the MC4R agonist RM-493 (Setmelanotide) lost an average of 13.5% of their body weight, with significant improvements in both insulin sensitivity and cardiovascular function

The result is a smoother, healthier-looking complexion