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There are tremendous challenges when transitioning other novel agents from bench-to-bedside, such as the issue of showing efficacy for regulatory approval when resistance develops so fast

However, while the cells from the familial control donor relied primarily on glycolysis for ATP production, the TDP-43 G376D Asymptomatic fibroblasts used glycolysis and OXPHOS equally

10.1016/j.jep.2023.117199 53 LiuC.MaX.ZhuangJ.LiuL.SunC

IUBMB Life 69 (6), 414422

However, due to a lengthy history of medical reductionism, the balance is currently heavily tilted towards splitting, which leads to difficulties when it comes to putting the patient back together [11]