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Dysbiosis amplifies barrier dysfunction and immune activation, while inflammation further perturbs microbial composition and impairs epithelial repair, establishing a self-sustaining pathological cycle

[DOI] [PMC free article] [PubMed] [Google Scholar] [92].Baines CP, Kaiser RA, Purcell NH, Blair NS, Osinska H, Hambleton MA, Brunskill EW, Sayen MR, Gottlieb RA, Dorn GW, Robbins J, Molkentin JD

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Goblet cell hyperplasia, metaplasia, and excessive mucus production are key pathological features of chronic airway diseases such as chronic obstructive bronchitis (part of COPD) and CF