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However, the clinical use of natural agonists is limited by poor bioavailability, while synthetic agents like thiazolidinediones are associated with adverse effects, including fluid retention, weight gain, and bone loss

Recent market developments and competitive strategies, such as expansion, type launch, development, partnership, merger, and acquisition, have been included to draw the competitive landscape in the market

10.1016/j.jshs.2014.10.004 47

This dose increases serum levels of -hydroxybutyrate by as much as 4 mM, similar to the level seen after two weeks of starvation, four times greater than what is seen after several weeks of a ketogenic diet, and up to 40 times higher than what is seen following an overnight fast, with levels returning to baseline after approximately 4 h [25]

Michalopoulos, G