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Synthesis of linear and cyclic peptides using the Ddz strategy Synthesis of linear peptide with Seg.Id.No: 4 Synthesis of cyclic peptide with Seg.Id.No: 9 Claims (16) A peptide consisting of 8 to 15 amino acid residues which is represented by the general formula:Xaa signifies a neutral aliphatic amino acid residue like Ala, bAla, Leu, Ile, Gly, Val, Nle, NvaYaa signifies a basic amino acid residue like Lys, Arg, Orn, His,Zaa signifies an acidic amino acid residue like Glu, Asp, Aad or Apm;wherein at least one of residues Xaa or Zaa can be omitted

On the other hand, Repatha (evolocumab, Amgen) used the Pushtronex system (Wests SmartDose) and Ultomiris (ravulizumab, Alexion) also used SmartDose to deliver 3.5 mL of solution

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