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Overall, spatial context and microenvironmental signals dynamically instruct TAM function, making these cells key drivers of disease progression and attractive therapeutic targets

Activated microglia in MS and EAE are associated with the production of several pro-inflammatory cytokines (IL-6, IL-1, IL-18, IL-12, IL-23, TNF-) and chemokines (CCL2, CCL3, CCL4, CCL5, CCL7, CCL12) (135)

Divekar R, Kita H

Reactive oxygen species formation and its effect on CD4+ T cell-mediated inflammation

The fungal T-2 toxin alters the activation of primary macrophages induced by TLR-agonists resulting in a decrease of the inflammatory response in the pig