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UGT1A proteins catalyse the covalent conjugation with glucuronic acid rendering lipophilic target substrates water soluble and inactive thereby facilitating biliary or renal elimination 17

Chandy posits a similar mechanism at play, suggesting that the swift reparative actions of B12 injections could momentarily overwhelm the body, leading to a temporary intensification of symptoms

Another study demonstrated that piperine significantly improved liver histology and inhibited the progression of diethylnitrosamine (DEN)-induced hepatocarcinoma in rats

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Analytical methods for FAMEs play a key role in the characterization and quantification of these compounds