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By performing gene set enrichment analysis (GSEA) limited to human-derived reads, we confirmed the upregulation of senescence and IFN- response signatures on palbociclib treatment and their downregulation when compared with palbociclib + RSL3-treated mice (Fig

In summary, SCLA1, SCLA2 and SCLA3 induced ferroptosis, which correlated with the identification of GPX4 as a target for these SCLAs in pulldown experiments and senescence selectivity of engagement with these SCLAs